Newer methods of regenerative therapy

Newer methods of regenerative therapy are based on biological agents. These include growth and differentiation agents, but also so-called enamel matrix proteins which promote the agglomeration, growth and differentiation of cells that are crucial for the structure of the periodontium. When these proteins are used, the original growth of the periodontium during the embryonic stage is imitated ("biological mimicry"). These proteins are developed from young pigs' teeth and, after the appropriate preparation, are available as a regenerative substance in the form of a gel. This protein mixture is applied to the root surface during a flap operation and may have a regenerative effect on the surrounding structures in the following weeks and months. Depending on the state of the defect, this method is also used in combination with other procedures, e.g. bone replacement material.


But all these procedures have one thing in common: primary wound healing is indispensable for their success. In other words, it is the decisive factor for the success of the treatment. This means, on the one hand, that an infection of the wound area must be avoided in all circumstances. This may be problematic due to patient-specific factors (general illnesses, oral hygiene and above all smoking) which may significantly impair the result. For this reason, the probability of achieving success through this kind of therapy should be discussed in advance in explicit consideration of the patient's potential risk factors. On the other hand, success depends on ensuring that for whatever material introduced, be it bone replacement material, a membrane or biological agents, complete wound closure and therefore adequate blood supply to the whole operated region is achieved. If this is not the case, the result may be impaired to such an extent that the therapy fails. To prevent this from happening, we use special surgical techniques that are precisely configured to the individual situation. Furthermore, we conduct the operations using microsurgical instruments that permit very fine and atraumatic work. Under these conditions, wound healing is better and faster. Finally, intensive OP-aftercare following the operation and the use by the patient at home of antimicrobial rinsing solutions are additional measures to prevent postoperative complications.